META-ANALYSIS – “The analysis of analyses”

 

Dr. V.K. Maheshwari 

M.A, M.Ed, Ph.D

Roorkee, India

 

Rakhi Maheshwari 

M.A, B.Ed

Noida, India

 

“Good data are always separable, with respect to their scientific importance, from the purposes for which they were obtained.”

Murray Sidman (1960) .Tactics of Scientific Research

It has became widely  accepted that the  best way to resolve  issues  on which there  are  a large number of studies is to carry out a meta-analysis. The  1980s and  1990s witnessed a rapid  upsurge  of this  statistical  approach  (Anastasi  and  Urbina,  1997).

Although commonly viewed as a relatively modern  advancement, the basic elements of meta-analysis can  be traced back to R. A. Fisher, who developed an early  quantitative procedure for combining the probabilities  from multiple hypothesis tests.

A common problem in many laboratories is that multiple studies are conducted on the same hypothesis and some way of “combining” the studies is sought. Often each study provides weak evidence but there may appear to be some consistency in findings across studies. A way of capturing that consistency is desired.

An equally common problem is that hundreds of studies accumulate in a research area. Here too there are likely to be many weak studies and considerable inconsistency  in study outcomes. A precise method for combining the studies would be desirable. An additional problem is that the studies may be different in a variety of ways.

Modern methods of meta-analysis were developed to solve this second kind of problem. The meta-analytic “revolution” began in the late 1970s. The psychotherapy outcome analysis published by Smith and Glass (1977) brought the method to the attention of many psychologists, highlighting its potential advantages. Smith and Glass (1977) examined over 300 therapy outcome studies and concluded that, overall, therapy was quite effective, placing the average treated person better off than 80% of untreated people.

 

Meta-analysis is a quantitative statistical analysis of several separate but similar experiments or studies in order to test the pooled data for statistical significance

Meta-analysis attempts to apply to a collection of studies the same methodological rigor and statistical precision ordinarily found in primary research.

In a meta-analysis, the collection of studies test the same conceptual hypothesis, but may do so using a wide variety of methods, measures, sample, and settings.

The challenge that meta-analysis answers is to provide a way to combine the seemingly disparate studies to provide a convincing overall test of the hypothesis and to explore its moderators.

 

Meta-analysis should be viewed as an observational study of the evidence. The steps involved are similar to any other research undertaking:

v Formulation of the problem to be addressed,

v Collection and analysis of the data,

v Reporting of the results.

Researchers should write in advance a detailed research protocol that clearly states the objectives, the hypotheses to be tested, the subgroups of interest, and the proposed methods and criteria for identifying and selecting relevant studies and extracting and analysing information.

Meta-analysis summarizes  the  results  of many  quantitative  studies  that  have  investigated  the  same problem.  It  provides  a  numerical  way  of expressing  the  average  result  of a  group  of studies.  It delineates specific procedures for finding,  describing,  classifying,  and  coding research studies to be included in a meta-analysis review, and for measuring and analysis of findings.

A central characteristic that distinguishes meta-analysis from more traditional approaches  is  the  emphasis  placed  on making  the  review  as  inclusive  as  possible.  This technique was first proposed by Glass (1976) and by the  end of the  1980s  it had become accepted as a useful method for synthesizing the results of many different studies.

Glass  distinguished  between Other Forms of Analysis the  primary,  secondary,  and  meta-analysis  of research.

Primary analysis is the original analysis of data in a research study.  The analysis of data from a single study to test the hypotheses originally formulated.

 

Secondary analysis is re-analysis  of data  for  the  purposes  of answering  the  original  research  question  with better  statistical  techniques,  or  answering  new  questions  with  all  data.  The re-analysis of data from a single study to test new hypotheses or to apply more appropriate statistical procedures to test the original hypotheses.

 

Meta-analysis refers to the analysis  of analyses; the statistical  analysis  of a large  collection of analysis results from individual studies for the purposes of integrating the findings. The application of statistical procedures to examine tests of a common hypothesis from more than one study.  It connotes  a rigorous  alternative  to  the  casual,  narrative  discussion  of research studies  which typify our attempts to make sense of the rapidly expanding research literature.It  contributes  in the  creation  of new knowledge synthesized from  existing studies.  The literature  explosion  has  resulted  in  a  massive  amount  of  information  that  must  be analyzed  and summarized  in  order to  be  useful.  Quantitative  methods  of integration  of research results  have  been  used  for  many  years  and  have  received  a  great  amount  of attention (Abraham et al.,  1991).

Meta-analysis  usually  involves  three  major  phases;  the  three  “Ps”:  preparation, performance,  and  presentation.  This  sequence  is  the  same  as  for  any  other  type  of research.  The project must be planned in  advance,  then systematically  carried  out,  then followed by reporting of results (Abraham et al.,  1991).

Any statistical procedure or analytic approach can be misused  or  abused.  As Green and Hall (1984) aptly stated “Data analysis is an aid to thought, not a substitute”. Most of the criticisms  of quantitative  approaches  to  reviewing  the  literature  are  objections  to  the misuse or abuse, real or potential, of meta-analysis.

Meta-analysis  is a statistical  approach to  the  aggregation summarization of results from independent studies. It is systematic, thorough, objective, and quantitative. The essentials of this  technique  are  to  collect  all  the  studies  on  the  issue,  convert  the  results  to  a common metric and average them to give an overall result. Procedures employed in meta- analysis  permit  quantitative  reviews  and  syntheses  of research  literature  that  address these issues (Wolf,  1986).  An epidemiologist has described meta-analysis  as  “a boon for policy makers who find themselves faced with a mountain of conflicting studies” (Mann, 1990).

Any  meta-analyst  has  to  address  three  problems  that  have  been  identified  by  Sharpe (1997)  as  the  “Apples  and  Oranges”,  “File  Drawer”  and  “Garbage  in  -  Garbage  out” problems.

The  “Apples  and  Oranges”  problem  refers  to  the  idea  that  different  phenomena  are sometimes aggregated and averaged, where disaggregation may show different effects for different  phenomena.  The  best  way  of dealing  with  this  problem  is  to  carry  out meta- analyses,  in the first instance,  on narrowly  defined phenomena and populations  and then attempt  to  integrate  these  into  broader  categories.

The  “File Drawer”  problem means that studies  producing significant  effects tend to  be published,  while  those  producing  non-significant  effects  tend  not  to  be  published  and remain unknown in the file drawer.

The  “Garbage  in – Garbage  out” problem  concerns  poor  quality studies.  Meta-analyses that  include  many  poor  quality  studies  have  been  criticized  by  Feinstein  (1995)  as “statistical alchemy” which attempt to turn a lot of poor quality studies into  good quality gold.  Poor quality studies are liable to obscure relationships that exist and can be detected by good quality studies. Meta-analysts differ in the  extent to which they judge studies to be  of such  poor  quality  that  they  should  be  excluded  from  the  analysis.  Some  meta- analysts  are  “inclusionist” while  others  are  “exclusionist”,  in the terminology suggested by Kraemer, Gardner, Brooks and Yesavage (1998).  This meta-analysis is “inclusionist” in the sense that it included all the studies on the Progressive Matrices among school and university students that have been located if the strict inclusion criteria apply to them.

The  next  problem  in  the  meta-analysis  was  to  obtain  all  the  studies  of the  issue  in concern.  This is a difficult problem and one that it is rarely and probably never possible to  solve  completely.

 

Although, there is no set pattern of the procedure of meta- analysis, still the widely used pattern is given below-

 

Steps to Perform a Meta-Analysis

  • Define the meta-analytic research question
  • Locate the relevant literature
  • Calculate effect sizes and code moderating variables
  • Analyze the meta-analytic database
  • Report and interpret the results

Step One -Define the Meta-Analytic Research Question

The purpose of this step is to determine what hypotheses your meta-analysis will test and to estimate the strength of an effect. At this stage we also determine moderators of an effect and determine what types of studies one will include in his analysis

The goals for this step are:

–       Hypotheses should have theoretical value

–       Should have specific inclusion criteria to make locating studies easier

–       Included studies should be appropriate for the hypotheses being tested

Step Two- Locate the relevant literature

The purpose of this step this step is to obtain the population of studies related to your research hypotheses and to modify the hypotheses and inclusion criteria of your analysis to better fit the literature .

 

  • Goals for this step

–       Should find every study that has investigated the effect of interest

–       Make your hypotheses better address the questions that researchers have investigated in primary research

Step Three- Calculate effect sizes and code moderating variables

The purpose of this step is to determine what effects you will examine in each study, Compute a specific estimate of the size of each effect and to determine the value of your moderating variables for each effect

  • Goals for this step

–       Accurately determine effect size estimates and moderator codes

–       Should try to have estimates for every effect

–       Typically have two different people calculate effect sizes and code moderators so you can estimate reliability

 

Step Four- Analyze the meta-analytic database

The purpose of this step is to perform descriptive analyses to determine the overall strength and consistency of the effect and perform moderator analyses to determine if study characteristics influence the effect size.

 

  • Goal for this step

–       Analyses should be valid

–       Analyses should directly answer the research questions

Step Five- Report and interpret the results

The purpose of this step is to summarize the results of your analyses, relate your analyses to the research questions and draw conclusions based on your analyses

 

  • Goals for this step

–       Verbally describe the implications of your analyses

–       Report any limitations you see regarding your analysis

  • Violation of assumptions
  • Power
  • Representativeness

Suggest areas of future research

 

Merits of Meta-analysis:

  • It increases power and leads to stronger conclusions because more studies can be analyzed with  statistical  methods  than the  impressionistic  literary  review.  Often this can bring effects into sharper focus, particularly when the results of all studies are not consistent (Higgins and Green, 2006).
  • Meta-analysis does not prejudge or exclude some studies as unworthy because of their particular  research  designs,  however  weak.  By  empirically  examining  the 241 effects  of research  quality  on study  findings,  meta-analysis  is  likely to  be more objective than traditional literary reviews (Wolf,  1986).
  • It  can answer questions not posed by the individual  studies (Higgins  and  Green, 2006).
  • It can settle controversies arising from apparently conflicting studies (Higgins and Green, 2006).

Limitations of Meta-analysis

•  It  oversimplifies  the  results  of a  research  domain  by  focusing  on  the  overall effects  and downplaying mediating or interaction effects. The  better examples of meta-analyses  built  potential  mediating  factors  into  their  designs  rather  than ignoring them. They do this by coding the characteristics of studies to empirically examine whether such interactions  exist.  In practice, many meta-analyses  do  not provide sufficient attention to possible interaction effects (Wolf,  1986).

•  Meta-analysis  of poor quality studies may  be  seriously misleading (Higgins  and Green, 2006).

•  Decisions  regarding  inclusion  and  exclusion  criteria  of studies  are  inevitably subjective.  In some  cases  consensus  may  be  hard  to  reach (Higgins  and  Green, 2006).

•  Meta-analysis  in  the  presence  of serious  publication  and/or reporting  bias  may produce an inappropriate summary (Higgins and Green, 2006).

Meta Analysis refers to a research strategy where instead of conducting new research with participants, the researchers examine the results of several previous studies. This is done with the purpose of gaining greater confidence in the results because of the larger pool of participants, as long as steps are taken to avoid errors that may have existed in the original studies.

 

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